٦٫٢٨ % | BlackRock Institutional Trust Company, N.A. | ٤٬٧٥٥٬٣١٨ | ٧٥٢٬٤٧٠ | ٣١/١٢/٢٠٢٣ |
٥٫١٣ % | Federated Hermes Global Investment Management Corp. | ٣٬٨٨٣٬٦٠٠ | ٥٠٠٬٠٠٠ | ٣١/١٢/٢٠٢٣ |
٤٫٦٩ % | Janus Henderson Investors | ٣٬٥٥١٬٨٩١ | ١٬٨٢٨٬٧٣١ | ٣١/١٢/٢٠٢٣ |
٤٫٦٥ % | T. Rowe Price Associates, Inc. | ٣٬٥٢١٬٩٩٩ | ٥٢٣٬٤٧٢ | ٣١/١٢/٢٠٢٣ |
٤٫٥٨ % | The Vanguard Group, Inc. | ٣٬٤٦٥٬٢٩٧ | ٥٠٤٬٢٧٥ | ٣١/١٢/٢٠٢٣ |
٣٫٩٥ % | State Street Global Advisors (US) | ٢٬٩٩١٬٨٩٩ | ٨٤٤٬٣٩٩ | ٣١/١٢/٢٠٢٣ |
٣٫٨٦ % | Adage Capital Management, L.P. | ٢٬٩٢٥٬٠٩٤ | ٦٣٨٬١٣٣ | ٣١/١٢/٢٠٢٣ |
٣٫٤٨ % | Deerfield Management Company, L.P. | ٢٬٦٣٠٬٢٩٢ | ٣٦١٬٦٦٤ | ٣١/١٢/٢٠٢٣ |
٢٫٩١ % | Boxer Capital, L.L.C. | ٢٬٢٠٢٬٨١٢ | 0 | ٣١/١٢/٢٠٢٣ |
٢٫٦١ % | Capital Research Global Investors | ١٬٩٧٦٬٨٧٠ | ٦٠٠٬٠٠٠ | ٣١/١٢/٢٠٢٣ |
٢٫٣٨ % | Logos Global Management LLC | ١٬٨٠٠٬٠٠٠ | -٤٥٠٬٠٠٠ | ٣١/١٢/٢٠٢٣ |
٢٫٢٨ % | BVF Partners L.P. | ١٬٧٢٩٬٠٤٣ | -٣٬٥٥٤٬٤٤٦ | ٣١/١٢/٢٠٢٣ |
٢٫٢٥ % | Holocene Advisors, LP | ١٬٧٠٠٬١٣٥ | ٦٦٧٬٢٠٤ | ٣١/١٢/٢٠٢٣ |
٢٫١٧ % | Citadel Advisors LLC | ١٬٦٤٣٬٢٩٣ | ٨٩٨٬١٩٣ | ٣١/١٢/٢٠٢٣ |
٢٫٠١ % | Avidity Partners Management LP | ١٬٥٢٠٬٠٠٠ | -٦٢٤٬٩٧١ | ٣١/١٢/٢٠٢٣ |
١٫٩٣ % | Sofinnova Investments, Inc | ١٬٤٥٨٬٨٨١ | ٤٢١٬٦٩٤ | ٣١/١٢/٢٠٢٣ |
١٫٧٩ % | Geode Capital Management, L.L.C. | ١٬٣٥١٬٣٣٧ | ١٩٠٬٢٣٢ | ٣١/١٢/٢٠٢٣ |
١٫٧٠ % | Dimensional Fund Advisors, L.P. | ١٬٢٨٦٬٣٠٠ | ١٤٤٬٠٥٨ | ٣١/١٢/٢٠٢٣ |
١٫٤٠ % | Baker Bros. Advisors LP | ١٬٠٦٢٬١٢٣ | 0 | ٣١/١٢/٢٠٢٣ |
١٫٣١ % | Morgan Stanley & Co. LLC | ٩٨٧٬٨٥١ | ٨٤٤٬٤٩٢ | ٣١/١٢/٢٠٢٣ |
١٫٢٤ % | Redmile Group, LLC | ٩٣٥٬٨٦٣ | ٩٣٥٬٨٦٣ | ٣١/١٢/٢٠٢٣ |
١٫٢١ % | Driehaus Capital Management, LLC | ٩١٢٬٧٨٦ | ٢١٥٬٣٢٥ | ٣١/١٢/٢٠٢٣ |
١٫١٦ % | Pictet Asset Management Ltd. | ٨٧٥٬٧٤٧ | ٢١١٬٦٥٧ | ٣١/١٢/٢٠٢٣ |
١٠٫٧٨ % | Fidelity Management & Research Company LLC | ٨٬١٦٠٬٢٠٦ | ٧٬٢٧١٬٩٩٧ | ٣١/١/٢٠٢٤ |
٠٫٩٠ % | Hata (Yujiro S.) | ٦٧٧٬٨٨٧ | 0 | ٩/٢/٢٠٢٤ |
٠٫٨٨ % | Platinum Asset Management | ٦٦٢٬٣٤٣ | -١٠٤٬٣٣٩ | ٣١/١٢/٢٠٢٣ |
٠٫٧٥ % | Soleus Capital Management, L.P. | ٥٦٤٬٧٠٠ | ٥٦٤٬٧٠٠ | ٣١/١٢/٢٠٢٣ |
٠٫٧١ % | Candriam Luxembourg S.A. | ٥٤٠٬٠٠٠ | ١٤٥٬٠٠٠ | ٢٩/٢/٢٠٢٤ |
٠٫٧١ % | Fisher Investments | ٥٣٩٬٦٧٦ | ٥٠٨٬١٥١ | ٣١/١٢/٢٠٢٣ |
٠٫٧٠ % | Boone Capital Management LLC | ٥٣١٬٩٦٧ | -٣٨٬٧١٥ | ٣١/١٢/٢٠٢٣ |
٠٫٧٠ % | D. E. Shaw & Co., L.P. | ٥٢٩٬٥٠٦ | ٩٣٬١٤٨ | ٣١/١٢/٢٠٢٣ |
٠٫٦٨ % | Dafna Capital Management, LLC | ٥١٦٬٣٤١ | ١٦٬٥٢١ | ٣١/١٢/٢٠٢٣ |
٠٫٦٨ % | Northern Trust Investments, Inc. | ٥١١٬٩٥٦ | ٦١٬٢٦٤ | ٣١/١٢/٢٠٢٣ |
٠٫٦٦ % | Charles Schwab Investment Management, Inc. | ٤٩٦٬٤٥٦ | ٥٩٬١٠٠ | ٣١/١٢/٢٠٢٣ |
٠٫٦٥ % | Ensign Peak Advisors, Inc. | ٤٩٠٬٠٣٩ | ١٢٦٬٢٥٥ | ٣١/١٢/٢٠٢٣ |
٠٫٦٢ % | Balyasny Asset Management LP | ٤٦٦٬٢٧١ | ٤٦٦٬٢٧١ | ٣١/١٢/٢٠٢٣ |
٠٫٥٩ % | Cormorant Asset Management, LP | ٤٥٠٬٠٠٠ | -١٥٠٬٠٠٠ | ٣١/١٢/٢٠٢٣ |
٠٫٥٥ % | Woodline Partners LP | ٤١٤٬٠٥٩ | ١٧٣٬٦٣١ | ٣١/١٢/٢٠٢٣ |
٠٫٥٢ % | Candriam Belgium S.A. | ٣٩٥٬٠١٩ | -٣٥٬٠٠٠ | ٣١/١٢/٢٠٢٣ |
٠٫٥١ % | First Turn Management, LLC | ٣٨٢٬٣٨٢ | ٣٨٢٬٣٨٢ | ٣١/١٢/٢٠٢٣ |
٠٫٥٠ % | Nuveen LLC | ٣٧٦٬٦٩٢ | -١٦٩٬٠٦١ | ٣١/١٢/٢٠٢٣ |
٠٫٤٦ % | Medical Strategy GmbH | ٣٤٩٬٤٤٧ | -٣٬٤٠٠ | ٣١/١٢/٢٠٢٣ |
٠٫٤٦ % | Victory Capital Management Inc. | ٣٤٦٬٤٩٠ | ٣٤٦٬٤٩٠ | ٣١/١٢/٢٠٢٣ |
٠٫٤٦ % | First Light Asset Management, LLC | ٣٤٥٬٦٧٤ | ٣٤٥٬٦٧٤ | ٣١/١٢/٢٠٢٣ |
٠٫٤٤ % | Eventide Asset Management, LLC | ٣٣٥٬٠٠٠ | 0 | ٣١/١٢/٢٠٢٣ |
٠٫٤١ % | Opaleye Management Inc. | ٣١١٬٥٠٠ | 0 | ٣١/١٢/٢٠٢٣ |
٠٫٤١ % | BlackRock Financial Management, Inc. | ٣٠٨٬٩٧٩ | ٦١٬٨١٤ | ٣١/١٢/٢٠٢٣ |
٠٫٣٣ % | Superstring Capital Management LP | ٢٥١٬٢٩٥ | ٢٥١٬٢٩٥ | ٣١/١٢/٢٠٢٣ |
٠٫٣٢ % | AXA Investment Managers UK Ltd. | ٢٤٣٬٢٨٠ | -١٠٠٬٤٧٥ | ٣١/١٢/٢٠٢٣ |
٠٫٣٠ % | Columbia Threadneedle Investments (US) | ٢٢٤٬١٤١ | -٤٩٬٣٣٢ | ٣١/١٢/٢٠٢٣ |
٠٫٢٩ % | Voya Investment Management LLC | ٢١٩٬٩٥٧ | -٧١٬١١٩ | ٣١/١٢/٢٠٢٣ |
٠٫٢٨ % | Goldman Sachs & Company, Inc. | ٢٠٨٬٤١٧ | -١٠٩٬٥٢٩ | ٣١/١٢/٢٠٢٣ |
٠٫٢٧ % | BNP Paribas Securities Corp. North America | ٢٠٧٬٧٣٥ | ١٥٥٬١٧٩ | ٣١/١٢/٢٠٢٣ |
٠٫٢٦ % | Walleye Capital LLC | ١٩٩٬٨٩١ | ١١٥٬٩٢٨ | ٣١/١٢/٢٠٢٣ |
٠٫٢٦ % | UBS Asset Management (Americas), Inc. | ١٩٦٬٣٢٩ | -٢٬٢٦٢ | ٣١/١٢/٢٠٢٣ |
٠٫٢٦ % | Invesco Capital Management LLC | ١٩٤٬٨٨٦ | -٧٢٬٨٩١ | ٣١/١٢/٢٠٢٣ |
٠٫٢٦ % | Rafferty Asset Management LLC | ١٩٣٬٣٥٦ | ٦٤٬٢٨٠ | ٣١/١٢/٢٠٢٣ |
٠٫٢٤ % | BofA Global Research (US) | ١٨٢٬٦٩٥ | ١٠٠٬٩٤٢ | ٣١/١٢/٢٠٢٣ |
٠٫٢٣ % | Barclays Bank PLC | ١٧٦٬٤٤٠ | ٩٠٬١١٤ | ٣١/١٢/٢٠٢٣ |
٠٫٢٢ % | BlackRock Investment Management, LLC | ١٦٧٬٦٥٦ | ٢٢٬٦٢٢ | ٣١/١٢/٢٠٢٣ |
٠٫٢١ % | Morgan Stanley Investment Management Inc. (US) | ١٥٦٬٩٨٣ | ١٥٥٬٨٣٦ | ٣١/١٢/٢٠٢٣ |
٠٫٢٠ % | BNY Mellon Asset Management | ١٥٣٬٥١٣ | ١١٬٥٠٧ | ٣١/١٢/٢٠٢٣ |
٠٫٢٠ % | UBS Financial Services, Inc. | ١٥٠٬٧٠٢ | ٩٤٬١٦٧ | ٣١/١٢/٢٠٢٣ |
٠٫١٨ % | Nantahala Capital Management, LLC | ١٣٩٬٢٩٨ | -٦٬٥٦٢ | ٣١/١٢/٢٠٢٣ |
٠٫١٨ % | Jennison Associates LLC | ١٣٨٬٢٤١ | ٣٧٬٣٤٥ | ٣١/٣/٢٠٢٤ |
٠٫١٨ % | TD Asset Management Inc. | ١٣٧٬٦٩٠ | ٢٤٬٠٣٤ | ٣١/١٢/٢٠٢٣ |
٠٫١٨ % | BlackRock Advisors (UK) Limited | ١٣٣٬٩٥٢ | ٩٬٠١٤ | ٣١/٣/٢٠٢٤ |
٠٫١٧ % | Parkman Healthcare Partners LLC | ١٣٠٬٢٦٥ | -٢٬٤٣٦ | ٣١/١٢/٢٠٢٣ |
٠٫١٧ % | HighVista Strategies LLC | ١٢٦٬٨٤٥ | 0 | ٣١/١٢/٢٠٢٣ |
٠٫١٦ % | First Trust Advisors L.P. | ١٢٠٬٦١٤ | ١٬٠٧٦ | ٣١/١٢/٢٠٢٣ |
٠٫١٦ % | Two Sigma Investments, LP | ١١٨٬٤٦٩ | -٩٠٬٨٣٩ | ٣١/١٢/٢٠٢٣ |
٠٫١٥ % | Nicholas Investment Partners, L.P. | ١١٠٬٣٥١ | ٩٤٬٠٩٤ | ٣١/١٢/٢٠٢٣ |
٠٫١٤ % | Allianz Global Investors GmbH | ١٠٩٬٥٠٥ | 0 | ٣١/١/٢٠٢٤ |
٠٫١٤ % | EAM Investors, LLC | ١٠٨٬١١٠ | ٢٠٬٤٤٨ | ٣١/١٢/٢٠٢٣ |
٠٫١٤ % | BlackRock Asset Management Ireland Limited | ١٠٧٬٢٧٧ | ٧٬٧٥٠ | ٣١/١٢/٢٠٢٣ |
٠٫١٢ % | Northern Trust Global Investments | ٩٣٬٥٥٥ | -٢٬٦٤١ | ٣١/١٢/٢٠٢٣ |
٠٫١٢ % | Manulife Investment Management (North America) Limited | ٩٢٬٤٣٨ | ١٤٬٠٢٨ | ٣١/١٢/٢٠٢٣ |
٠٫١٢ % | Citi Investment Research (US) | ٨٩٬٦٩٨ | ٣٤٬٤٤٤ | ٣١/١٢/٢٠٢٣ |
٠٫١١ % | Rhumbline Advisers Ltd. Partnership | ٨٥٬٩٦٦ | ٧٬١٧٢ | ٣١/١٢/٢٠٢٣ |
٠٫١١ % | Schweizerische Nationalbank | ٨٥٬١٠٠ | -٢١٬٩٠٠ | ٣١/١٢/٢٠٢٣ |
٠٫١١ % | Hudson Bay Capital Management LP | ٨٤٬٥٠٠ | ٤٩٬٥٠٠ | ٣١/١٢/٢٠٢٣ |
٠٫١١ % | Wellington Management Company, LLP | ٨٣٬٩٨٤ | ٨٣٬٩٨٤ | ٣١/١٢/٢٠٢٣ |
٠٫١٠ % | Qube Research & Technologies Ltd | ٧٧٬٥١٦ | ٤٢٬١٦٢ | ٣١/١٢/٢٠٢٣ |
٠٫١٠ % | Parametric Portfolio Associates LLC | ٧٧٬٢٠٤ | -٣٩٧ | ٣١/١٢/٢٠٢٣ |
٠٫١٠ % | UBS O'Connor LLC | ٧٤٬٥٧٥ | -٥١٬٥٧٤ | ٣١/١٢/٢٠٢٣ |
٠٫٠٩ % | HOOPP Investment Management | ٧١٬٠٠٠ | ٧١٬٠٠٠ | ٣١/١٢/٢٠٢٣ |
٠٫٠٩ % | Goldman Sachs Asset Management, L.P. | ٦٩٬٧٤٩ | -٣٢٬٣٢٧ | ٣١/١٢/٢٠٢٣ |
٠٫٠٩ % | MFS Investment Management | ٦٥٬٠٠١ | -١١٬١٤٥ | ٢٩/٢/٢٠٢٤ |
٠٫٠٨ % | Credit Suisse Funds AG | ٦٢٬٦١٠ | ١٬٣٠٠ | ٣١/١٢/٢٠٢٣ |
٠٫٠٨ % | Campbell & Company, Inc. | ٦١٬٢٢٦ | ٢٩٬٥٣٦ | ٣١/١٢/٢٠٢٣ |
٠٫٠٨ % | DWS Investment GmbH | ٦٠٬٠٠٠ | ٥٧٬٠٣٨ | ٣١/١٢/٢٠٢٣ |
٠٫٠٨ % | AllianceBernstein L.P. | ٥٧٬٦٨٠ | ٧٬١٤٠ | ٣١/١٢/٢٠٢٣ |
٠٫٠٧ % | UBS Asset Management (Switzerland) | ٥٦٬٠٦٢ | ٥٬٣٥٦ | ٣١/١٢/٢٠٢٣ |
٠٫٠٧ % | Capstone Investment Advisors, LLC | ٥٥٬٢٣٩ | ٥٥٬٢٣٩ | ٣١/١٢/٢٠٢٣ |
٠٫٠٧ % | Mellon Investments Corporation | ٥٤٬٧١٧ | ٧٬٨٩٦ | ٣١/١٢/٢٠٢٣ |
٠٫٠٧ % | State of Wisconsin Investment Board | ٥٢٬٩٧٦ | -١١٬١٣٤ | ٣١/١٢/٢٠٢٣ |
٠٫٠٧ % | Deka Vermögensmanagement GmbH | ٥٠٬٠٠٠ | 0 | ٣١/١٢/٢٠٢٣ |
٠٫٠٧ % | Legal & General Investment Management Ltd. | ٤٩٬٤٥٢ | -١٬١٢٢ | ٣١/١٢/٢٠٢٣ |
٠٫٠٦ % | Dimensional Fund Advisors, Ltd. | ٤٨٬٤٧٨ | ٣٬١٠٦ | ٣١/١/٢٠٢٤ |
٠٫٠٦ % | California State Teachers Retirement System | ٤٨٬٣٥٩ | -٦٬٦٥٩ | ٣١/١٢/٢٠٢٣ |